UC Irvine struck for three second half goals to doom the Bisons on the road in southern California.
After a two-goal performance on Friday night, senior forward Ivan Sakou grabbed his first ASUN weekly honor.
The Bisons face the No. 23 Anteaters on Monday night coming off back-to-back golden goal victories.
Ivan Sakou tied the game in the 84th minute and won it in the 113th as he brought the Bisons back from a 2-1 deficit to beat San Diego 3-2.
The Bisons will make the longest road trip in program history as they head to California to play San Diego on Friday night.
After an overtime win on Saturday against Georgia St. the Bisons got back in the region poll at No. 8.
After scoring all three of the Bisons goals this week, junior Logan Paynter took home the ASUN's Player of the Week award.
Senior Ivan Alvarado's 18th career assist led to Logan Paynter's golden goal as the Bisons topped Georgia St. 1-0 in overtime.
The Bisons are 0-9 in the Divison I era against the Panthers, but will look to break the losing streak at home on Saturday night.
Two goals by Logan Paynter weren't enough as the Bisons lost 3-2 to former ASUN rival ETSU in overtime.